Drew Brees/Michael Thomas/Mark Ingram: New Orleans will pile up the points in a classic SuperDome shootout, and Brees is especially dynamic after a bye week.
Deshaun Watson/DeAndre Hopkins: Cleveland is no match for this duo. Hopkins’ 38% target share leads the league by a big margin.
Jerick McKinnon: McKinnon’s 22 touches for a total of 146 yards show Minnesota will feature him going forward. Latavius Murray is not a threat.
NYG offense: The Giants lost four receivers last week. Now, they get rewarded with the league’s most imposing defense.
Jay Ajayi/Jarvis Landry, Miami: Devante Parker’s injury should equal optimism for these two, but Jay Cutler has this offense playing in quicksand.
Carlos Hyde, San Francisco: Hyde (11 rushing yards last week) was out-touched by UDFA Matt Breida and will suffer from negative game-script.