Sunday, 1 p.m.
New England at NY Jets: Tom Brady is the top QB play despite a left shoulder injury. Chris Hogan’s consistent role and red-zone consistency has him as my preferred WR1 over Brandin Cooks. Rob Gronkowski seems close to 100%, which is to say he’s the obvious TE1 overall. RB2 Mike Gillislee is TD dependent, but he has a great chance for paydirt in this one. Danny Amendola, James White and Dion Lewis are all worth rostering. It’s a great matchup for McCown and Co. against NE’s porous defense, but I expect the 300-yard passer streak to end here. Bilal Powell (calf) is out, so RB2 Elijiah McGuire is the preferred backfield option even with Matt Forte returning. WR3 Jermaine Kearse and TE1 Austin Seferian-Jenkins will benefit from negative game-script.
Green Bay at Minnesota:WR1 Jordy Nelson (back) is back practicing in full, but high-end WR2 Davante Adams is seeing significant targets and seems to be picking up where he left off in 2016. Ty Montgomery’s (ribs) status is up in the air, but Aaron Jones is a great RB2 if he sits. WR3 Randall Cobb and fringe TE1 Martellus Bennett are afterthoughts in the passing game. Stefon Diggs’ (groin) status is anyone’s guess, potentially elevating WR2 Adam Thielen. RB2 Jerick McKinnon is the clear favorite for backfield work, and is a great DFS play.
San Francisco @ Washington: SF will be playing from behind, but Pierre Garcon should muster WR2 production without Josh Norman’s presence. RB2 Carlos Hyde’s 11 rushing yards last week is a screaming reminder of a his downside. George Kittle is on the TE1 radar. This is a great spot for QB1 Kirk Cousins, but predicting his targets will be tough. WR2 Terrelle Pryor always carries big upside, while Jay Gruden plans to re-emphasize WR3 Jamison Crowder. TE1 Jordan Reed is healthy, for now. PPR RB2/3 Chris Thompson is a fine play with Rob Kelley sidelined.
Cleveland at Houston: Another new starting QB for the Browns. Avoid this offense aside from PPR RB2 Duke Johnson. Rookie sensation Deshaun Watson’s TD rate may be unsustainable, but this is a smash spot for he and elite WR1 DeAndre Hopkins. Lamar Miller is a fine RB1 after playing 88 percent of snaps last week. WR3 Will Fuller is big-play dependent.
Detroit at New Orleans: QB1 Matthew Stafford will need to throw early and often in this shootout, benefiting WR1/2 Golden Tate. DET is force-feeding RB2 Ameer Abdullah, who has yet to reward them. WR3 Marvin Jones is volume-dependent, but this is a good matchup. Nothing is safer than the QB-WR stack of Drew Brees and Michael Thomas this week. RB2s Mark Ingram and Alvin Kamara will receive slightly much touches after Adrian Peterson’s departure.
Chicago at Baltimore: RB1/2 Jordan Howard will be a focal point, albeit against a stingy Baltimore rush defense. TE2 Zach Miller is worth a flier due to his fairly consistent targets. Flex option Tarik Cohen has faded precipitously. RB2 Buck Allen is the best bet for production in the Ravens’ limited offense, but Baltimore’s D is a top option at home against a rookie QB.
Miami at Atlanta: Jay Cutler’s putrid offense is best avoided, but WR2 Jarvis Landry should see significant targets with Devante Parker doubtful. RB2 Jay Ajayi will get carries, but is TD-dependent with no receiving role. WR1 Julio Jones is still dealing with a nagging hip ailment, but this is a very inviting matchup in what projects to be a blowout. RB1 Devonta Freeman has a great track record as a signficant home favorite.
Sunday, 4:05-4:25 p.m.
Tampa Bay at Arizona: Mike Evans is a locked-in WR1, but Patrick Peterson’s presence is worth considering in DFS. WR3 DeSean Jackson, on the other hand, has a great matchup. RB1/2 Doug Martin looked great after returning from suspension and may become an offensive focal point. Cameron Brate remains on the radar as a fringe TE1. Low-end QB1 and WR1s respectively, Carson Palmer and Larry Fitzgerald face an exploitable TB secondary. RB2/3 Andre Ellington has carved out a consistent PPR role.
LA Rams at Jacksonville: RB1 Todd Gurley’s workhorse role should be reinstated after peculiar play-calling last week. Jacksonville’s rush D is ripe for the picking. Similarly, RB1 Leonard Fournette is guaranteed at least 20 carries, as always, against a LA defense best attacked on the ground.
Pittsburgh at Kansas City: Ben Roethlisberger’s subpar play downgrades the ceiling of this entire offense. Still, Le’Veon Bell and Antonio Brown are unquestionably among the top options at their positions. PIT will need to score to keep this game close. Elite RB1 Kareem Hunt has yet to produce less than 100 scrimmage yards in his NFL career. High-end WR2 Tyreek Hill is dealing with a hamstring injury, but should play. TE1 Travis Kelce (concussion) is tentatively expected to play.
Sunday, 8:30 p.m.
NY Giants at Denver: TE1 Evan Engram will be needed as a receiver with the carnage dealt to NYG’s wideouts last week. He is the only play here despite his inexplicable goose-egg a week ago. RB1 C.J. Anderson figures to be the centerpiece of Denver’s game plan in a contest that may get out of hand, but WR2s Emmanuel Sanders and Demaryius Thomas are always safe plays.
Monday, 8:30 p.m.
Indianapolis at Tennessee: This is an appetizing matchup for fringe WR1 T.Y. Hilton, but his home/road splits are significantly in favor of Lucas Oil. Frank Gore is an uninspiring RB3 with Marlon Mack expected to cut into his workload. Marcus Mariota projects as a game-time decision; it’s safer to leave him on the bench. RB2 DeMarco Murray will get a solid workload in a plus matchup. Delanie Walker remains a fine TE1.
E-mail Endicott College freshman Will Homonnay of North Andover at email@example.com, or follow him on Twitter @WillHomonnay.