Sunday, 1 p.m.
Miami at New England: Matt Moore appears likely to start at QB with Jay Cutler in the concussion protocol. High-end WR2 Jarvis Landry maintains steady value in PPR formats, while Devante Parker is just a WR3. Tom Brady is the clear overall QB1, and WR1 Brandin Cooks should be able to wreak havoc against Miami’s overmatched secondary. TE1 Rob Gronkowski should play through his illness, though his ceiling is much lower than in past years. RB2 Dion Lewis is the preferred member of NE’s backfield trio.
Carolina at NY Jets:QB1 Cam Newton appeared close to MVP form before his bye week with RB1 Christian McCaffrey operating as the engine of Carolina’s offense. Greg Olsen (foot) will return as a low-end TE1 while Devin Funchess is a volume-dependent WR2. WR3 Robby Anderson boasts a significant weekly ceiling, but Josh McCown’s offense is best avoided against a formidable Panther defense.
Chicago at Philadelphia: RB2 Jordan Howard is the only member of Chicago’s offense worth considering, and negative game-script is a major concern. QB1 Carson Wentz will put up big numbers as long as the contest stays close, and TE1 Zach Ertz should rebound from a sluggish Week 11 performance. WR2 Alshon Jeffery and RB2 Jay Ajayi have matchup advantages as secondary options in the offense.
Tennessee at Indianapolis: Fringe QB1 Marcus Mariota has a mouth-watering matchup against Indy’s defense. RB1/2 DeMarco Murray will handle the most touches, while Delanie Walker is always a sure bet for steady production. For the Colts, TE1 Jack Doyle deserves the benefit of the doubt despite a quiet Week 10. WR2 T.Y. Hilton is capable of exploding every week, but predicting when is a tough proposition.
Tampa Bay at Atlanta: WR1 Mike Evans still hasn’t surpassed 100 receiving yards in any game this season. The rest of Ryan Fitzpatrick’s offense should be ignored against a surging Atlanta defense. WR1 Julio Jones’ theoretical value remains much higher than his weekly production due to OC Steve Sarkisian’s ineptitude and Jones’ questionable health. Tevin Coleman will operate as a high-end RB2 with Devonta Freeman (concussion) likely to miss a second consecutive game. WR3 Mohamed Sanu commands consistent targets.
Buffalo at Kansas City: RB1 LeSean McCoy faces a reeling KC defense allowing 129 weekly rushing yards as Buffalo’s offensive centerpiece. The only thing standing between Kareem Hunt’s return to elite RB1 status against the Bills’ league-worst run defense is Andy Reid’s questionable usage. Travis Kelce has vaulted Gronk as the overall TE1 while Tyreek Hill is a high-end WR2.
Cleveland at Cincinnati: RB2 Duke Johnson is Cleveland’s only reliable fantasy option, and only in PPR formats. WR4 Corey Coleman is worth rostering. Elite WR1 A.J. Green has a dream matchup versus the Browns, while RB2 Joe Mixon will continue his role as Cincy’s featured runner.
Sunday, 4:05-4:25 p.m.
Seattle at San Francisco: Elite QB1 Russell Wilson is the only thing keeping Seattle from the NFL’s basement given their numerous defensive injuries. WR1 Doug Baldwin and TE1 Jimmy Graham will be fed ample targets in this high-volume passing attack. Keep an eye on J.D. McKissic’s usage for PPR.
New Orleans at LA Rams: The elite RB1 duo of Mark Ingram and Alvin Kamara are matchup-proof; Ingram has scored 8 TDs since Adrian Peterson was traded. QB1 Drew Brees and WR1 Michael Thomas may be needed more against a powerful LA offense. Fire up elite RB1 Todd Gurley with confidence now that Robert Woods has been ruled out. WR2/3 Cooper Kupp will see increased targets, as will disappointing WR4 Sammy Watkins.
Jacksonville at Arizona: RB1 Leonard Fournette re-emerged as Jacksonville’s feature back to the tune of 28 carries. WR3 Marqise Lee remains on the radar. WR2 Larry Fitzgerald’s value takes a big hit due to Jacksonville’s elite secondary. RB2 Adrian Peterson is TD-dependent due to inefficiency.
Denver at Oakland: Paxton Lynch is making his first start of the season, which doesn’t do much to affect WR2s Demaryius Thomas and Emmanuel Sanders. QB2 Derek Carr appears injured as Oakland’s season is circling the drain. Low-end WR2s Michael Crabtree and Amari Cooper will struggle to produce against Denver’s still-capable CBs.
Sunday, 8:30 p.m.
Green Bay at Pittsburgh: WR2 Davante Adams is clearly Brett Hundley’s favorite target; WR4 Jordy Nelson is safe to drop in all leagues given this offense’s grave status. WR1 Antonio Brown and RB1 Le’Veon Bell are obviously elite players at their respective positions, but a big lead presents a concern to their late-game usage. WR2 Juju Smith-Schuster is a weekly big-play threat.
Monday, 8:30 p.m.
Houston at Baltimore: Fringe WR1 DeAndre Hopkins will rebound from last week’s tough matchup with Patrick Peterson. RB2 Lamar Miller will struggle for efficiency against Baltimore’s formidable front seven. Baltimore’s offense is best avoided in what should be an ugly defensive battle, but WR3 Jeremy Maclin and RB3 Alex Collins are relevant options for desperate owners.
E-mail Endicott College freshman Will Homonnay of North Andover at firstname.lastname@example.org, or follow him on Twitter @WillHomonnay.