Sunday, 1 O’clock
Buffalo at Cincinnati: RB1 LeSean McCoy’s rushing numbers haven’t been up to his standards, but a steady receiving role buoys his PPR floor. TE1 Charles Clay’s 100 yard-performance last week illustrated his current standing as QB2 Tyrod Taylor’s top target. Buffalo’s defense has been impressive, but A.J. Green remains a mid-range WR1 due to his heavy usage rate. Joe Mixon disappointed to the tune of 1.71 YPC, but his 17 carries show Cincy wants to make him their workhorse. TE2 Tyler Kroft just had the best game of his career.
NY Jets at Cleveland: RB2 Bilal Powell’s 163 rushing yards look great on paper, but he had just 4.4 YPC if his 75-yarder is removed. Austin Seferian-Jenkins is a consistent option on the TE1 fringe with a sparkling matchup. RB2 Duke Johnson is the only safe bet for production in Cleveland’s woeful offense with 17 targets in the last two contests. RB3 Isaiah Crowell is worth a dart throw against an exploitable NYJ run defense.
Arizona at Philadelphia: QB1 Carson Palmer is averaging over 45 passing attempts per game, which is a boon for high-end WR2 Larry Fitzgerald. PPR RB2 Andre Ellington (14 targets last week) is the safest tertiary option, while the Brown twins are simply WR3 dart throws. CB Patrick Peterson is a threat to the outlook of low-end WR2 Alshon Jeffery. Elite TE1 Zach Ertz will benefit in this high-volume passing attack. The timeshare keeps LeGarrette Blount and Wendell Smallwood as game-script dependent RB2s.
LA Chargers at NY Giants: QB2 Philip Rivers will need to pass to stay competitive here. NYG’s pass defense isn’t as scary as it was last year, keeping Keenan Allen afloat as a WR1. Melvin Gordon likely needs a TD in order to return RB1 value. WR3 Tyrell Williams showcased his every-week upside with a long TD last week. Without a significant rushing attack, Eli Manning will be throwing short, quick passes to WR1 Odell Beckham. SD CBs present tough matchups for WR3s Brandon Marshall and Sterling Shepard, boosting the stock of Evan Engram, who has seen nine targets per game the last two weeks.
San Francisco at Indianapolis: RB1 Carlos Hyde is the best play here despite a nagging hip injury. WR2 Pierre Garcon should also be involved with Marquise Goodwin likely to be sidelined. WR4 Aldrick Robinson is worth a look after seeing 12 targets last week. It’s an inviting matchup for WR2 T.Y. Hilton, who was able to take advantage of a similar matchup two weeks ago. RB2 Frank Gore’s role remains steady in an offensive committed to running the football.
Tennessee at Miami: Marcus Mariota’s (hamstring) status remains up in the air, putting the outlook of this game in question. TE1 Delanie Walker’s value remains secure regardless, while WR3 Rishard Matthews is downgraded a bit. High-end RB2 DeMarco Murray receives a significant usage bump if Mariota sits, as does RB3 Derrick Henry. If QB2 Jay Cutler is unable to bounce back to a Tennessee defense that allowed 50+ points to Houston last week, this offense can be officially buried. WR2s Devante Parker and Jarvis Landry benefit from the team’s lack of target distribution. RB1/2 Jay Ajayi has strangely faded from his Week 1 workhorse role.
Carolina at Detroit: Fringe QB1 Cam Newton showed positive signs against NE’s league-worst defense, but things get much tougher in this spot. WR2 Kelvin Benjamin will have to deal with the likes of Darius Slay, likely promoting frustratingly unpredictable RB2 Christian McCaffrey into a productive PPR role. Devin Funchess remains on the WR3 radar. QB1 Matthew Stafford should have no trouble passing against Carolina, elevating Golden Tate to high-end WR2 status. RB2 Ameer Abdullah’s career-high 20 carries clearly show he is preferred over Flex Theo Riddick.
Jacksonville at Pittsburgh: RB1 Leonard Fournette is averaging 20 carries per contest, which keeps his floor intact despite potential negative game-script. Choosing between dart throw WR4s Allen Hurns and Marqise Lee is splitting hairs. Le’Veon Bell’s 38 touches last week prove his training wheels have been removed. Fire him up as this week’s top play. WR1 Antonio Brown is slightly less preferable again Jacksonville’s strong secondary. Martavis Bryant remains a boom-bust WR3 in a ground-focused attack.
Sunday, 4:05-4:25 p.m.
Baltimore at Oakland: RB3 Alex Collins’ emergence as Baltimore’s early-down back limits Buck Allen to a fringe Flex play in PPR leagues. Jeremy Maclin is an inconsistent WR3. With Derek Carr (back) sidelined, E.J. Manuel torpedoes the outlook for WR3s Amari Cooper and Michael Crabtree. RB2 Marshawn Lynch is likely to remain in neutral.
Seattle at LA Rams: QB1 Russell Wilson will need to put up points to keep pace with LA’s potent offense. Fringe WR1 Doug Baldwin is his best target despite typically struggling on the road. Volume keeps Jimmy Graham slightly afloat despite his maddening dearth of red-zone looks. RB1 Todd Gurley’s bounce-back campaign faces its biggest test against Seattle’s defense. WR3 Sammy Watkins has a concerning floor, but his ceiling remains high.
Green Bay at Dallas: The elite battery of Aaron Rodgers - Jordy Nelson is bankable in this prospective shootout. Randall Cobb is the preferred WR2 due to the murky status of WR3 Davante Adams (concussion). GB’s ground game is a situation to avoid with Ty Montgomery’s (ribs) status up in the air. TE1 Martellus Bennett has a large range of outcomes. Dak Prescott is a favorite QB1 in this revenge spot for last season’s playoff loss. Elite RB2 Ezekiel Elliott is a virtual lock for paydirt, while WR1 Dez Bryant matches up well against GB’s secondary. Jason Witten is a fine TE1.
Sunday, 8:30 p.m.
Kansas City at Houston: MVP frontrunner Kareem Hunt remains matchup proof; he has yet to produce less than 100 yards from scrimmage. Fringe WR1 Tyreek Hill is always a big play threat while Travis Kelce’s in Week 5’s overall TE1. There is reason for both excitement and trepidation in this spot for QB1/2 Deshaun Watson, but DeAndre Hopkins is a locked-in WR1. RB2 Lamar Miller’s receiving role keeps him ahead of D’Onta Foreman for now.
Monday, 8:30 p.m.
Minnesota at Chicago: Stefon Diggs is on the WR1 borderline against Chicago’s talent-deficient secondary. WR2 Adam Thielen will also have room to operate. Latavius Murray is just a TD-dependent RB3 until his role shakes out. RB2s Jordan Howard and Tarik Cohen remain Chicago’s only worthwhile fantasy options. QB Mitch Trubisky faces an uphill battle in his debut under center.
E-mail Endicott College freshman Will Homonnay of North Andover at firstname.lastname@example.org, or follow him on Twitter @WillHomonnay.